Sensory and Neuromotor System Disorders CRO
In vivex is a preclinical Contract Research Organization ( CRO )
specialized in the evaluation of sensory and neuromotor system disorders
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Preclinical validated models
Motor and sensory system
Hearing
Ophthalmology
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PK studies
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Technical platforms
Behavioral tests
Electrophysiology
In vitro and histology
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Efficacy study
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Efficay study
Choose your preclinical efficacy study
1
Select your pharmacological candidate
Chemical molecules
Proteins & antibodies
Virus ( GENE THERAPY )
Stem cells ( CELL THERAPY )
2
Select your administration route
Oral gavage ( per os )
Intraperitoneal
Intramuscular
Intravenous
Subcutaneous
Intrathecal
Intranerve
Intravitreal ( eye )
Transtympanic ( inner ear )
3
Select your preclinical model
Neuromotor & neuromuscular systems
Nerve injury neuropathy
Charcot Marie Tooth disease
Neuropathic pain
Diabetic neuropathy
Spinal cord injury
Age related neuropathy
Chemotherapy induced neuropathy
Amyotrophic lateral sclerosis
Duchenne muscular dystrophy
Inflammatory neuropathy
Hearing
Noise-induced hearing loss
Age related hearing loss
Tinnitus
Antibiotic-induced hearing loss
Cisplatin-induced hearing loss
Ophthalmology
Diabetic retinopathy
Age related blindness
Glaucoma
Congenic retinal degeneration
4
Select your readouts
Behavorial tests
Rotarod
Grip test
Balance beam test
Inverted screen Kondziela test
Mechanical pain using Von Frey test
Thermal pain using Thermal gradient test
Gap Prepulse Inhibition Startle Reflex
Optometry test for visual acuity
Electrophysiology
Electromyogram
Nerve conduction velocity and amplitude
Auditory brainstem responses
Distortion Product Otoacoustic emission
Spontaneous activity of auditory cortex in tinnitus
Electroretinogram
Histology
Peripheral nerve histology ( axons and myelin )
Cytocochleogram
Retina histology
Ultrastructure electron microscopy
Intraepidermal nerve fibers
In vitro analysis
Biomarker analysis by ELISA
Protein analysis by Western blot
5
Select your report
SHORT EFFICACY STUDY REPORT
Fast report including results and statistical analysis ( 10 days )
COMPLETE REGULATORY EFFICACY STUDY REPORT
Large report including graph results, raw data, description of results and complex statistical analysis ( 4 weeks )
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