Pharmacokinetic studies

Pharmacokinetic studies attempt to analyze chemical metabolism and to discover the fate of a new pharmacological candidate from the moment that it is administered up to the point at which it is completely eliminated from the body. PK study is a mandatory step for the development of efficacy studies increasing the potential success of the new drug candidate.

Administration►

Transtympanic ( inner ear )

Intravitreal

Oral gavage ( per os )

Intravenous

Intraperitoneal

Intramuscular

Subcutaneous

Intranerve

Type of pharmacological
candidate►

Molecules

Viral particles

Antibodies

Small proteins

Sampling►

Cochlear perilymph

Vitreous and aqueous humor

Cerebrospinal fluid ( CSF )

Blood

Brain areas

Spinal cord

Organs and tissues

Bioanalysis

Immuno assay ELISA

HPLC

Mass spectrometry

Gene array

Protein array

Histological analysis

Example
Pharmacokinetic study of chemotherapy cisplatin in mice